Conformational polymorphism in sofosbuvir: some structural insights

Structural insights into the conformational variability of FtsZ.

FtsZ is a prokaryotic homologue of the eukaryotic cytoskeletal protein tubulin and plays a central role in prokaryotic cell division. Both FtsZ and tubulin are known to pass through cycles of polymerization and depolymerization, but the structural mechanisms underlying this cycle remain to be determined. Comparison of tubulin structures obtained in different states has led to a model in which t...

Structural Insights into Conformational Changes Required for Kinesin Motility

single nucleotide polymorphism and asthma: from conformational variations to structural alternations

background: asthma is the main reason of disability, health resource exploitation and low quality of life for those who are affected. it is estimated that nearly 300 million people in the world are suffering from asthma. studies have identified 18 genomic regions and more than 100 genes associated with asthma. among these candidate genes, il-17f plays a very interesting role in asthma. this stu...

Conformational polymorphism or structural invariance in DNA photoinduced lesions: implications for repair rates

DNA photolesions constitute a particularly deleterious class of molecular defects responsible for the insurgence of a vast majority of skin malignant tumors. Dimerization of two adjacent thymines or cytosines mostly gives rise to cyclobutane pyrimidine dimers (CPD) and pyrimidine(6-4)pyrimidone 64-PP as the most common defects. We perform all-atom classical simulations, up to 2 μs, of CPD and 6...

Structural Polymorphism

This paper describes structural polymorphism, a new form of type polymorphism appropriate to functional languages featuring user-defined algebraic data types (e.g., Standard ML, Haskell and Miranda1). The approach extends the familiar notion of parametric polymorphism by allowing the definition of functions which are generic with respect to data structures as well as to individual types. For ex...